Modified out-of-box fields, business rules, or script includes that conflict with new upgrade changes to the same records. (high likelihood)
Customized UI policies, client scripts, or ACLs on base system tables that overlap with upgrade modifications. (high likelihood)
Direct modifications to base system workflows, notification rules, or scheduled jobs that are being updated in the new release. (medium likelihood)
Custom dictionary overrides or table extensions that conflict with base system schema changes in the upgrade. (medium likelihood)
Modified system properties or application configurations that are being changed by the upgrade package. (low likelihood)